What is Secondary Osteoporosis?

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Osteoporosis is a bone disease that involves a loss of bone density. It causes the bones to become more fragile and prone to fractures. Secondary osteoporosis develops either as a result of a medical condition or as a side effect of a medication.

Osteoporosis affects about 10 million people in the United States. The disease may be primary or secondary. Primary osteoporosis occurs as a result of the natural aging process, whereas secondary osteoporosis occurs due to other reasons.
This article describes the difference between primary and secondary osteoporosis. It also outlines the possible causes of secondary osteoporosis and provides information on the symptoms, diagnosis, and treatment options.

Primary vs. secondary osteoporosis

Doctors categorize osteoporosis into primary and secondary osteoporosis.
Primary osteoporosis is a consequence of the aging process. In females, hormones such as estrogen and progesterone decline after menopause. These hormones are essential for healthy bones, and when their levels are low, the body becomes less able to produce new, healthy bone tissue.
Secondary osteoporosis develops when an underlying medical condition or the use of a certain medication interferes with the body’s ability to produce new bone tissue.

Causes of secondary osteoporosis

Secondary osteoporosis may develop when certain medical conditions or medications interrupt the formation of new bone tissue. An imbalance between the loss of old bone and the production of new bone leads to a lower bone turnover rate. The result is a loss of bone density.

Medical conditions

Medical conditions that may lead to secondary osteoporosis include:

  • hyperparathyroidism
  • hyperthyroidism
  • diabetes
  • inflammatory bowel disease (IBD)
  • rheumatoid arthritis
  • lupus
  • celiac disease
  • chronic kidney disease
  • liver disease
  • ankylosing spondylitis
  • multiple myeloma
  • multiple sclerosis (MS)
  • anorexia nervosa


In most cases, secondary osteoporosis occurs as a result of taking certain medications, which include those below.

Hormones and medications that affect the endocrine system

The endocrine system is a network of glands that produce and secrete hormones for a wide range of bodily functions. Hormones and other medications that affect the endocrine system may cause secondary osteoporosis. Examples include:

  • thyroid hormone
  • glucocorticoids
  • thiazolidinediones
  • hypogonadism-inducing agents:
    • aromatase Inhibitors
    • medroxyprogesterone acetate
    • gonadotropin-releasing hormone (GnRH) agonists

Medications that affect the immune system

The immune system consists of various organs, cells, and proteins that work together to protect the body from pathogens and toxins. Medications that affect the immune system may cause secondary osteoporosis. Examples include antiretroviral therapy and calcineurin inhibitors.

Medications that act on the central nervous system

The central nervous system (CNS) consists of the brain and spinal cord. Medications that affect the CNS can increase the risk of secondary osteoporosis. These include anticonvulsants and antidepressants.

Medications that affect the gastrointestinal tract

The gastrointestinal tract consists of all the organs involved in the digestive process. Medications that affect the gastrointestinal tract can increase the risk of secondary osteoporosis. An example is proton pump inhibitors, which reduce the production of stomach acid.


People with osteoporosis are usually unaware that they have the condition, as they typically do not experience any symptoms. Often, people only receive a diagnosis of osteoporosis following a bone break from a fall or sudden impact.
The most common injuries associated with osteoporosis are:

  • broken hip
  • broken wrist
  • broken vertebrae

As the bones become increasingly fragile, people may experience fractures in other parts of the body. Seemingly harmless activities, such as sneezing or coughing, can sometimes cause these fractures.
Some older people with the condition may develop a stooped posture due to bone fractures within the spine.


A doctor will perform a thorough medical examination to look for conditions that may cause secondary osteoporosis. They will also take a full medical history to help identify any medications that may be associated with the condition.
Simple screening procedures can help identify possible causes of secondary osteoporosis. These procedures may include:

  • testing blood or other bodily fluids for the following:
    • metabolic bone markers
    • protein
    • electrolytes
    • blood cell count
    • creatinine
    • calcium
    • alkaline phosphates
    • liver enzymes
  • blood tests to assess thyroid function
  • DEXA or ultrasound scans to assess bone density

New Mexico Orthopaedics is a multi-disciplinary orthopaedic clinic located in Albuquerque New Mexico. We have multiple physical therapy clinics located throughout the Albuquerque metro area.
New Mexico Orthopaedics offers a full spectrum of services related to orthopaedic care and our expertise ranges from acute conditions such as sports injuries and fractures to prolonged, chronic care diagnoses, including total joint replacement and spinal disorders.
Because our team of highly-trained physicians specialize in various aspects of the musculoskeletal system, our practice has the capacity to treat any orthopaedic condition, and offer related support services, such as physical therapy, WorkLink and much more.
If you need orthopedic care in Albuquerque New Mexico contact New Mexico Orthopaedics at 505-724-4300.